PRODUCTS

Integrity™ LevMixer®

The Integrity™ LevMixer® system is specifically designed to fulfill the needs of the Bioprocess industry. This system is a mobile, flexible mixing system that allows efficient and reproducible single use mixing of a wide range of volumes in a broad series of applications ranging from buffer preparation to final formulation. The LevMixer system is engineered for use with ATMI single-use mixing bags in cGMP certified cleanrooms without complex instrumentation to control the mixing process.

The LevMixer consists of an interchangeable superconducting drive unit and proprietary levitating impeller based disposable mixing bags fitted into containers on either a portable dolly or a floor mounted tank. Once properly charged and coupled with the mixing bag, the activation of the motor induces levitation and rotation of the in-bag impeller resulting in effective mixing action inside a hermetically sealed bag. Coupling of the in-bag impeller with the drive motor requires no dynamic seals or shaft penetration inside the bag. The drive motor is enclosed on a portable cart that can be easily disconnected from the bag and reconnected to another mixing bag, allowing mixing in multiple bags of various sizes with a single drive unit.

As with all ATMI LifeSciences' single-use mixing systems, the LevMixer utilizes disposable mixing bags made from Integrity TK8 bioprocess film. The product-contacting layer of TK8 film is blow-extruded in-house by ATMI under cleanroom conditions using medical-grade ultra low-density polyethylene resin. It is then laminated to create a gas barrier film of exceptional cleanliness, strength, and clarity that is animal derived component free (ADCF) and complies fully with USP Class VI requirements.

Lev Mixer
  • Quicker time to market
  • Rapid process changeover
  • Faster development and production cycles
  • Ergonomic, easy to operate and control hardware
  • Portable universal drive (all bag sizes)
  • Accommodates scaling from 6L to 2,000L (based on min. mix volume)
  • Simple and quick bag installation
  • Reduced capital investment
  • Higher return on investment
  • Increased throughput & Improved facility utilization
  • Ultra-clean; no shafts, seals or bearings inside the mixing bag
  • Ensure materials integrity across mulit-product manufacturing facilities
Lev Mixer
  • Purification
  • Suspension / re-suspension
  • Final formulation, fill
  • Harvesting
  • Media, buffer preparation
Lev Mixer

The mixing technology of the Integrity LevMixer system is based on non-contact magnetic coupling between conventional permanent magnets in the impeller and superconducting material in the drive. Superconducting material has the ability to trap the magnetic field generated by the permanent magnets and "lock the magnetic field in memory" in an equilibrium position. The trapped magnetic field behaves like mechanical springs; if the magnet is moved up, down or sideways by outside forces (e.g., gravity or angular torque) it will tend to be pulled back to an equilibrium position. The peculiar nature of magnet-superconductor interaction ties the two bodies together resulting in a very stable mechanical couple with finite equilibrium separation. This peculiar stability cannot be attained in conventional mixer designs that employ two permanent magnets. In these mixers, the two magnets strongly attract one another and exert that force on the bearing in the impeller. Thus, the magnet-superconductor couple is the basis for a revolutionary design of the non-contact magnetic levitation mixer.

The Cryogenic temperatures (approx. -200° C) required for the superconducting material are achieved by an internal cryocooler (Sterling cycle refrigerator), which operates on 115V or 230V 50/60 Hz AC power. The motor requires no dynamic seals or shaft penetration inside the bag. The drive motor is mounted on a portable cart that can be easily disconnected from the bag and reconnected to another mixing bag thereby allowing mixing in multiple bags of various sizes with a single drive unit.

Lev Mixer